• Corpus ID: 18886846

Genomic Risk for Severe Canine Compulsive Disorder , a Dog Model of Human OCD

@inproceedings{Dodman2016GenomicRF,
  title={Genomic Risk for Severe Canine Compulsive Disorder , a Dog Model of Human OCD},
  author={Nicholas H. Dodman and Edward I. Ginns and Louis Shuster and Alice A. Moon-Fanelli and Marzena Galdzicka and Jiashun Zheng and Alison L. Ruhe and Mark William Neff},
  year={2016}
}
Dogs naturally suffer the same complex diseases as humans, including mental illness. The dog is uniquely suited as a model organism to explore the genetics of neuropsychiatric disorders. Historical breed demographics have enriched purebred populations for founder effect mutations with tractable architectures, making genotypic analyses advantageous. Over a pet’s lifetime, owners observe the animal’s stress tolerance, arousal, and anxiety, and can inform on rich behavioral profiles for phenotypic… 

Figures and Tables from this paper

Evolutionary and functional data power search for obsessive-compulsive disorder genes

The findings suggest synaptic adhesion as a key function in compulsive behaviors across three species, and demonstrate how combining targeted sequencing with functional annotations can identify potentially causative variants in both coding and noncoding regions, even when genomic data is limited.

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608

Canine lineages reveal genetic drivers of dog behavioral diversification

This work overcome longstanding difficulties in identifying genetic drivers of canine behavior by developing an innovative framework for understanding relationships between breeds and the behaviors that define them utilizing a dataset of over 4,000 domestic, semi-feral and wild canids and behavioral survey data for over 46,000 dogs.

Establishing a canine brain and tissue bank – molecular validation by RT-qPCR targeting three reference genes

The molecular quality of tissues collected in the Canine Brain and Tissue Bank’s donations system can fit in the standards of dog gene expression analyses, based on the results.

Man’s best friend in life and death: scientific perspectives and challenges of dog brain banking

An overview about the current state of dog biobanking is provided and the "Canine Brain and Tissue Bank" (CBTB) is introduced-a new, large-scale collaborative endeavor in the field.

Development and validation of the Canine Reward Responsiveness Scale –Examining individual differences in reward responsiveness of the domestic dog

The findings are informative with regard to the dog as an animal model for various human behavioural and cognitive functions‚ and also for the dog in its own right as they are relevant to training and welfare.

Veterinary informatics: forging the future between veterinary medicine, human medicine, and One Health initiatives—a joint paper by the Association for Veterinary Informatics (AVI) and the CTSA One Health Alliance (COHA)

The current state of veterinary medical electronic health records and the ability to aggregate and analyze large datasets from multiple organizations and clinics are reviewed and various methods of veterinary informatics including natural language processing and machine learning techniques are reviewed.

Spiegeldanio : A bold and aggressive fish but what if it loses a fight?

The spiegeldanio (spd) strain of zebrafish (Danio rerio), which has a mutation in the fibroblast growth factor receptor 1a, is Bolde rerio, which is a competition based survival strategy.

References

SHOWING 1-10 OF 83 REFERENCES

Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder

The limited genetic diversity of dog breeds facilitates identification of genes, functional variants and regulatory pathways underlying complex psychiatric disorders that are mechanistically similar in dogs and humans.

Natural animal models of human psychiatric conditions: assessment of mechanism and validity

  • K. Overall
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2000

Brain structural abnormalities in Doberman pinschers with canine compulsive disorder

Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes

Clinical features and severity of probands carrying the uncommon non-synonymous variants suggest that CDH2, along with other cadherin and cell adhesion genes, is an interesting gene to pursue as a plausible contributor to OCD, TD and related disorders with repetitive behaviors, including autism spectrum disorders.

Genetic and environmental influences on obsessive-compulsive disorder

The significant challenges for identifying risk factors for OCD as well as promising avenues for overcoming these obstacles are considered and the value of focusing on certain phenotypes, applying a dimensional approach, and investigating possible endophenotypes are discussed.

Pharmacogenetics of obsessive-compulsive disorders.

Recent findings regarding candidate genes which may influence drug response, including those in the serotonin system, brain-derived neurotrophic factor and the glutamate transporter gene are focused on, which may be highly relevant to drug response.

A canine chromosome 7 locus confers compulsive disorder susceptibility

These findings highlight the negative consequences of PEMCS on the brain and behavior of adolescence and suggest that the a6 nAChR subunit may modify, at least in part, these effects.

Neural mechanisms of decision making in hoarding disorder.

Findings suggest a biphasic abnormality in anterior cingulate cortex and insula function in patients with HD related to problems in identifying the emotional significance of a stimulus, generating appropriate emotional response, or regulating affective state during decision making.
...