• Corpus ID: 18886846

Genomic Risk for Severe Canine Compulsive Disorder , a Dog Model of Human OCD

  title={Genomic Risk for Severe Canine Compulsive Disorder , a Dog Model of Human OCD},
  author={Nicholas H. Dodman and Edward I. Ginns and Louis Shuster and Alice A. Moon-Fanelli and Marzena Galdzicka and Jiashun Zheng and Alison L. Ruhe and Mark William Neff},
Dogs naturally suffer the same complex diseases as humans, including mental illness. The dog is uniquely suited as a model organism to explore the genetics of neuropsychiatric disorders. Historical breed demographics have enriched purebred populations for founder effect mutations with tractable architectures, making genotypic analyses advantageous. Over a pet’s lifetime, owners observe the animal’s stress tolerance, arousal, and anxiety, and can inform on rich behavioral profiles for phenotypic… 

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