Genomic Rearrangements of PTEN in Prostate Cancer

@inproceedings{Phin2013GenomicRO,
  title={Genomic Rearrangements of PTEN in Prostate Cancer},
  author={Sopheap Phin and Mathew W. Moore and Philip D. Cotter},
  booktitle={Front. Oncol.},
  year={2013}
}
The phosphatase and tensin homolog gene (PTEN) on chromosome 10q23.3 is a negative regulator of the PIK3/Akt survival pathway and is the most frequently deleted tumor suppressor gene in prostate cancer. Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss of PTEN in prostate cancer is linked to metastasis and androgen-independent progression. Studies on the genomic status of PTEN in prostate cancer initially used a two-color fluorescence in situ… CONTINUE READING

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Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss of PTEN in prostate cancer is linked to metastasis and androgen - independent progression .
Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss of PTEN in prostate cancer is linked to metastasis and androgen - independent progression .
Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss of PTEN in prostate cancer is linked to metastasis and androgen - independent progression .
Monoallelic loss of PTEN is present in up to 60% of localized prostate cancers and complete loss of PTEN in prostate cancer is linked to metastasis and androgen - independent progression .
PTEN geneGene associated with diseaseProstate carcinoma
Genomic Rearrangements of PTEN in Prostate Cancer .
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