Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice

@inproceedings{Panguluri2010GenomicPO,
  title={Genomic Profiling of Messenger RNAs and MicroRNAs Reveals Potential Mechanisms of TWEAK-Induced Skeletal Muscle Wasting in Mice},
  author={Siva K. Panguluri and Shephali Bhatnagar and Akhilesh Kumar and John J McCarthy and Apurva K. Srivastava and Nigel G. F. Cooper and Robert F. Lundy and Ashok Kumar},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Skeletal muscle wasting is a devastating complication of several physiological and pathophysiological conditions. Inflammatory cytokines play an important role in the loss of skeletal muscle mass in various chronic diseases. We have recently reported that proinflammatory cytokine TWEAK is a major muscle-wasting cytokine. Emerging evidence suggests that gene expression is regulated not only at transcriptional level but also at post-transcriptional level through the expression of… CONTINUE READING
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