Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

  title={Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse},
  author={B. Bernstein and M. Kamal and K. Lindblad-Toh and S. Bekiranov and D. Bailey and Dana J. Huebert and Scott W. McMahon and E. Karlsson and E. Kulbokas and T. Gingeras and S. Schreiber and E. Lander},
  • B. Bernstein, M. Kamal, +9 authors E. Lander
  • Published 2005
  • Biology, Medicine
  • Cell
  • We mapped histone H3 lysine 4 di- and trimethylation and lysine 9/14 acetylation across the nonrepetitive portions of human chromosomes 21 and 22 and compared patterns of lysine 4 dimethylation for several orthologous human and mouse loci. Both chromosomes show punctate sites enriched for modified histones. Sites showing trimethylation correlate with transcription starts, while those showing mainly dimethylation occur elsewhere in the vicinity of active genes. Punctate methylation patterns are… CONTINUE READING
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