• DOI:10.1016/j.cell.2005.01.001
Corpus ID: 7193829

Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse

@article{Bernstein2005GenomicMA,
  title={Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse},
  author={B. Bernstein and M. Kamal and K. Lindblad-Toh and S. Bekiranov and D. Bailey and Dana J. Huebert and Scott W. McMahon and E. Karlsson and E. Kulbokas and T. Gingeras and S. Schreiber and E. Lander},
  journal={Cell},
  year={2005},
  volume={120},
  pages={169-181}
}

B. Bernstein, M. Kamal, +9 authors E. Lander

Published 2005

Biology, Medicine

Cell

We mapped histone H3 lysine 4 di- and trimethylation and lysine 9/14 acetylation across the nonrepetitive portions of human chromosomes 21 and 22 and compared patterns of lysine 4 dimethylation for several orthologous human and mouse loci. Both chromosomes show punctate sites enriched for modified histones. Sites showing trimethylation correlate with transcription starts, while those showing mainly dimethylation occur elsewhere in the vicinity of active genes. Punctate methylation patterns are… CONTINUE READING

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