Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules

@article{Poos2015GenomicHO,
  title={Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules},
  author={K. Poos and J. Smida and Doris Maugg and G. Eckstein and D. Baumhoer and M. Nathrath and E. Korsching},
  journal={PLoS ONE},
  year={2015},
  volume={10}
}
  • K. Poos, J. Smida, +4 authors E. Korsching
  • Published 2015
  • Biology, Medicine
  • PLoS ONE
  • Osteosarcoma (OS), a bone tumor, exhibit a complex karyotype. On the genomic level a highly variable degree of alterations in nearly all chromosomal regions and between individual tumors is observable. This hampers the identification of common drivers in OS biology. To identify the common molecular mechanisms involved in the maintenance of OS, we follow the hypothesis that all the copy number-associated differences between the patients are intercepted on the level of the functional modules. The… CONTINUE READING
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