Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules

@inproceedings{Poos2015GenomicHO,
  title={Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules},
  author={Kathrin Poos and Jan Smida and Doris Maugg and Gertrud N Eckstein and Daniel Baumhoer and Michaela Nathrath and Eberhard Korsching},
  booktitle={PloS one},
  year={2015}
}
Osteosarcoma (OS), a bone tumor, exhibit a complex karyotype. On the genomic level a highly variable degree of alterations in nearly all chromosomal regions and between individual tumors is observable. This hampers the identification of common drivers in OS biology. To identify the common molecular mechanisms involved in the maintenance of OS, we follow the hypothesis that all the copy number-associated differences between the patients are intercepted on the level of the functional modules. The… CONTINUE READING
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