Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

@article{Holden2009GenomicEF,
  title={Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens},
  author={Matthew T. G. Holden and Zoe Heather and Romain Paillot and Karen Frances Steward and Katy S Webb and Fern Ainslie and Thibaud Jourdan and Nathalie C. Bason and Nancy Holroyd and Karen Mungall and Michael A. Quail and Mandy Sanders and Mark Simmonds and David Willey and Karen L. Brooks and David M. Aanensen and Brian G. Spratt and Keith A. Jolley and Martin C J Maiden and Michael Kehoe and Neil Chanter and Stephen D. Bentley and Carl Peter Robinson and Duncan J Maskell and Julian Parkhill and Andrew Waller},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={292 - 299}
}
The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi subspecies equi (S. equi) is a host-restricted pathogen of horses that has evolved from the zoonotic pathogen Streptococcus equi subspecies zooepidemicus (S. zooepidemicus). These pathogens share approximately 80% genome sequence identity with the important human pathogen… CONTINUE READING

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