Genomic Disorders in Psychiatry—What Does the Clinician Need to Know?

@article{Lowther2017GenomicDI,
  title={Genomic Disorders in Psychiatry—What Does the Clinician Need to Know?},
  author={Chelsea Lowther and G. Costain and D. Baribeau and A. Bassett},
  journal={Current Psychiatry Reports},
  year={2017},
  volume={19},
  pages={1-10}
}
  • Chelsea Lowther, G. Costain, +1 author A. Bassett
  • Published 2017
  • Medicine, Psychology
  • Current Psychiatry Reports
  • Purpose of ReviewThe purpose of this review is to summarize the role of genomic disorders in various psychiatric conditions and to highlight important recent advances in the field that are of potential clinical relevance.Recent FindingsGenomic disorders are caused by large rare recurrent deletions and duplications at certain chromosomal “hotspots” (e.g., 22q11.2, 16p11.2, 15q11-q13, 1q21.1, 15q13.3) across the genome. Most overlap multiple genes, affect development, and are associated with… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 103 REFERENCES
    Advancing epilepsy genetics in the genomic era
    104