Genomic DNA as a cohybridization standard for mammalian microarray measurements.

@article{Williams2004GenomicDA,
  title={Genomic DNA as a cohybridization standard for mammalian microarray measurements.},
  author={Brian A. Williams and Richele M Gwirtz and Barbara J. Wold},
  journal={Nucleic acids research},
  year={2004},
  volume={32 10},
  pages={e81}
}
A persistent design problem for ratiometric microarray studies is selecting the 'denominator' RNA cohybridization standard. The ideal standard should be readily available, inexpensive, invariant over time and from laboratory to laboratory, and should represent all genes with a uniform signal. RNA references (both commercial 'universal' and experiment--specific types), fall short of these goals. We show here that mouse genomic DNA is a reliable microarray cohybridization standard which can meet… CONTINUE READING

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