Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study

@inproceedings{Swaminathan2011GenomicCN,
  title={Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study},
  author={Shanker Swaminathan and Sungeun Kim and Li Shen and Shannon L. Risacher and Tatiana Foroud and Nathan Pankratz and Steven G. Potkin and Matthew J. Huentelman and David W. Craig and Michael W Weiner and Andrew J. Saykin and A TheAlzheimer'sDiseaseNeuroimagingInitiative},
  booktitle={International journal of Alzheimer's disease},
  year={2011}
}
Copy number variants (CNVs) are DNA sequence alterations, resulting in gains (duplications) and losses (deletions) of genomic segments. They often overlap genes and may play important roles in disease. Only one published study has examined CNVs in late-onset Alzheimer's disease (AD), and none have examined mild cognitive impairment (MCI). CNV calls were generated in 288 AD, 183 MCI, and 184 healthy control (HC) non-Hispanic Caucasian Alzheimer's Disease Neuroimaging Initiative participants… CONTINUE READING