Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum

@article{Mudge2008GenomicCA,
  title={Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum},
  author={Joann Mudge and Neil A Miller and Irina Khrebtukova and Ingrid E. Lindquist and Gregory D. May and Jim J. Huntley and Shujun Luo and Lu Zhang and Jennifer C. van Velkinburgh and Andrew D. Farmer and Sharon E Lewis and William D. Beavis and Faye D. Schilkey and Selene M. Virk and C. Forrest Black and Margaret Myers and Lar C. Mader and Ray J. Langley and John P. Utsey and Ryan W. Kim and Rosalinda C. Roberts and Sat Kirpal Khalsa and Meredith M. Garcia and Victoria Ambriz-Griffith and Richard C Harlan and Wendy Czika and Stanton L. Martin and Russell D. Wolfinger and Nora I. Perrone-Bizzozero and Gary P. Schroth and Stephen F Kingsmore},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={120 - 126}
}
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar cortices of 14 patients and six, matched controls. A rigorous analysis pipeline was developed for analysis of digital gene expression studies. Sequences aligned to approximately 33,200 transcripts in… CONTINUE READING
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