Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

@article{Watkins2015GenomicCP,
  title={Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.},
  author={Johnathan Watkins and Daniel B Weekes and Vandna Shah and Patrycja Gazinska and Shalaka R Joshi and Bhavna Sidhu and Cheryl E. Gillett and Sarah E. Pinder and Fabio Vanoli and Maria Jasin and Markus Mayrhofer and Anders Isaksson and Maggie C U Cheang and Hasan Mirza and Jessica R. Frankum and Christopher J Lord and Alan A. Ashworth and Shaveta Vinayak and James M. Ford and Melinda L. Telli and Anita Grigoriadis and Andrew N J Tutt},
  journal={Cancer discovery},
  year={2015},
  volume={5 5},
  pages={488-505}
}
UNLABELLED Triple-negative breast cancers (TNBC) are characterized by a wide spectrum of genomic alterations, some of which might be caused by defects in DNA repair processes such as homologous recombination (HR). Despite this understanding, associating particular patterns of genomic instability with response to therapy has been challenging. Here, we show that allelic-imbalanced copy-number aberrations (AiCNA) are more prevalent in TNBCs that respond to platinum-based chemotherapy, thus… CONTINUE READING
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