Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing

@article{Wang2019GenomicCO,
  title={Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation Sequencing},
  author={Yao Wang and M. Yu and J. Yang and D. Cao and Y. Zhang and H. Zhou and Z. Yuan and K. Shen},
  journal={Frontiers in Oncology},
  year={2019},
  volume={9}
}
Endometrial intraepithelial neoplasia (EIN), also known as endometrial atypical hyperplasia (EAH) is believed to be the precursor lesion of endometrioid endometrial carcinoma (EEC). Many genetic factors play important roles in the process of carcinogenesis, however, the key genetic alterations from dysplasia to endometrial cancer remains poorly understood. Germline mutations in Lynch syndrome genes are associated with hereditary endometrial carcinoma. The role of other cancer susceptibility… Expand
5 Citations

Figures, Tables, and Topics from this paper

References

SHOWING 1-10 OF 75 REFERENCES
Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma.
  • 16
  • Highly Influential
PIK3CA and PTEN Mutations in Uterine Endometrioid Carcinoma and Complex Atypical Hyperplasia
  • 196
  • PDF
Integrated genomic characterization of endometrial carcinoma
  • D. Levine, Gad Stacey B. Kristian Eric Andrey Carrie Mike Cyriac Getz Gabriel Cibulskis Lander Sivachenko Sougnez L, +271 authors H. Sofia
  • Biology, Medicine
  • Nature
  • 2013
  • 2,521
  • Highly Influential
  • PDF
Endometrial cancer and somatic G>T KRAS transversion in patients with constitutional MUTYH biallelic mutations.
  • 17
...
1
2
3
4
5
...