Genomic Characterization of Primary Invasive Lobular Breast Cancer.

  title={Genomic Characterization of Primary Invasive Lobular Breast Cancer.},
  author={Christine Desmedt and Gabriele Zoppoli and Gunes Gundem and Giancarlo Pruneri and Denis P Larsimont and Marco Fornili and Debora Fumagalli and David Brown and Françoise Roth{\'e} and Delphine Vincent and Naima Kheddoumi and Ghizlane Rouas and Samira Majjaj and Sylvain Broh{\'e}e and Peter Van Loo and Patrick Maisonneuve and Roberto Salgado and Thomas Van Brussel and Diether Lambrechts and Ron Bose and Otto Metzger and Christine C. Galant and François Bertucci and Martine J. Piccart-Gebhart and Giuseppe Viale and Elia Biganzoli and Peter J. Campbell and Christos Sotiriou},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={34 16},
PURPOSE Invasive lobular breast cancer (ILBC) is the second most common histologic subtype after invasive ductal breast cancer (IDBC). Despite clinical and pathologic differences, ILBC is still treated as IDBC. We aimed to identify genomic alterations in ILBC with potential clinical implications. METHODS From an initial 630 ILBC primary tumors, we interrogated oncogenic substitutions and insertions and deletions of 360 cancer genes and genome-wide copy number aberrations in 413 and 170 ILBC… CONTINUE READING
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