Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer

@article{Hua2009GenomicAB,
  title={Genomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer},
  author={Sujun Hua and Ralf Kittler and Kevin P White},
  journal={Cell},
  year={2009},
  volume={137},
  pages={1259-1271}
}
Retinoic acid (RA) triggers antiproliferative effects in tumor cells, and therefore RA and its synthetic analogs have great potential as anticarcinogenic agents. Retinoic acid receptors (RARs) mediate RA effects by directly regulating gene expression. To define the genetic network regulated by RARs in breast cancer, we identified RAR genomic targets using chromatin immunoprecipitation and expression analysis. We found that RAR binding throughout the genome is highly coincident with estrogen… CONTINUE READING
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