Genomic Analysis of the Vaccinia Virus Strain Variants Found in Dryvax Vaccine

@article{Qin2011GenomicAO,
  title={Genomic Analysis of the Vaccinia Virus Strain Variants Found in Dryvax Vaccine},
  author={Li Qin and Chris Upton and Bart Hazes and David H. Evans},
  journal={Journal of Virology},
  year={2011},
  volume={85},
  pages={13049 - 13060}
}
ABSTRACT Smallpox was eradicated using variant forms of vaccinia virus-based vaccines. One of these was Dryvax, a calf lymph vaccine derived from the New York City Board of Health strain. We used genome-sequencing technology to examine the genetic diversity of the population of viruses present in a sample of Dryvax. These studies show that the conserved cores of these viruses exhibit a lower level of sequence variation than do the telomeres. However, even though the ends of orthopoxviruses are… 
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