Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications

@inproceedings{Chen2017GenomicAO,
  title={Genomic Analysis of Tumor Microenvironment Immune Types across 14 Solid Cancer Types: Immunotherapeutic Implications},
  author={Yu-Pei Chen and Yu Zhang and Jia-Wei Lv and Ying-qin Li and Ya-qin Wang and Qing-mei He and Xiao-jing Yang and Ying Sun and Y P Mao and Jing-ping Yun and Na Liu and Jun Ma},
  booktitle={Theranostics},
  year={2017}
}
We performed a comprehensive immuno-genomic analysis of tumor microenvironment immune types (TMITs), which is classified into four groups based on PD-L1+CD8A or PD-L1+cytolytic activity (CYT) expression, across a broad spectrum of solid tumors in order to help identify patients who will benefit from anti- PD-1/PD-L1 therapy. The mRNA sequencing data from The Cancer Genome Atlas (TCGA) of 14 solid cancer types representing 6,685 tumor samples was analyzed. TMIT was classified only for those… CONTINUE READING