Genomic Analysis Identifies Targets of Convergent Positive Selection in Drug Resistant Mycobacterium tuberculosis

@inproceedings{Farhat2013GenomicAI,
  title={Genomic Analysis Identifies Targets of Convergent Positive Selection in Drug Resistant Mycobacterium tuberculosis},
  author={Maha R. Farhat and B. Jesse Shapiro and Karen J. Kieser and Razvan Sultana and Karen R Jacobson and Thomas Calldo Victor and Robin Mark Warren and Elizabeth M Streicher and Alistair Calver and Alex Sloutsky and Devinder Kaur and Jamie E Posey and Bonnie B. Plikaytis and Marco R Oggioni and Jennifer L. Gardy and James Cameron Johnston and Mabel Rodrigues and Patrick K. C. Tang and Midori Kato-Maeda and Mark L. Borowsky and Bhavana Muddukrishna and Barry Kreiswirth and Natalia E. Kurepina and James E. Galagan and S{\'e}bastien Gagneux and Bruce W. Birren and Eric J. Rubin and Eric S. Lander and Pardis C Sabeti and Megan B Murray},
  booktitle={Nature Genetics},
  year={2013}
}
M. tuberculosis is evolving antibiotic resistance, threatening attempts at tuberculosis epidemic control. Mechanisms of resistance, including genetic changes favored by selection in resistant isolates, are incompletely understood. Using 116 newly sequenced and 7 previously sequenced M. tuberculosis whole genomes, we identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains. By searching for convergent evolution—the independent fixation of mutations in the… CONTINUE READING
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