Genomic Alterations in the RB Pathway Indicate Prognostic Outcomes of Early-Stage Lung Adenocarcinoma.

@article{Choi2015GenomicAI,
  title={Genomic Alterations in the RB Pathway Indicate Prognostic Outcomes of Early-Stage Lung Adenocarcinoma.},
  author={Seongmin Choi and Hyeong Ryul Kim and Chang Ohk Sung and Jongkyu Kim and Seon Young Kim and Sung-Min Ahn and Chang Min Choi and Sung-min Chun and Eun Kyung Choi and Sang-We Kim and Yong-Hee Kim and Ji-Young Lee and Joon Seon Song and Deokhoon Kim and Farhan Ul Haq and Sun Young Lee and Jong-Eun Lee and Wang-rim Jung and Hye Yoon Jang and Eunho Yang and Charles Lee and Eunsil Yu and Geoffrey K.-W. Kong and Daehyun Baek and Se Jin Jang},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 11},
  pages={
          2613-23
        }
}
PURPOSE To better understand the complete genomic architecture of lung adenocarcinoma. EXPERIMENTAL DESIGN We used array experiments to determine copy number variations and sequenced the complete exomes of the 247 lung adenocarcinoma tumor samples along with matched normal cells obtained from the same patients. Fully annotated clinical data were also available, providing an unprecedented opportunity to assess the impact of genomic alterations on clinical outcomes. RESULTS We discovered that… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours.

  • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
  • 2007
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Non-small cell lung cancer, version 2.2013.

  • Journal of the National Comprehensive Cancer Network : JNCCN
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Outcome following lung resections for pT1 non-small cell lung cancer.

  • European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
  • 2006
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Cyclin dependent kinases in cancer: potential for therapeutic intervention

CanaveseM, L Santo, N. Raje
  • Cancer Biol Ther 2012;13:451–7. www.aacrjournals.org Clin Cancer Res;
  • 2015
VIEW 1 EXCERPT