Genomic Aberrations in Lung Adenocarcinoma in Never Smokers

  title={Genomic Aberrations in Lung Adenocarcinoma in Never Smokers},
  author={Bastien Job and Alain Bernheim and Mich{\'e}le Beau-Faller and Sophie Camilleri-Br{\"o}et and Philippe Girard and P. Hofman and Julien Mazi{\`e}res and Saloua Toujani and Ludovic Lacroix and Julien Laffaire and Philippe Dessen and Pierre Jean Fouret},
  booktitle={PloS one},
BACKGROUND Lung cancer in never smokers would rank as the seventh most common cause of cancer death worldwide. METHODS AND FINDINGS We performed high-resolution array comparative genomic hybridization analysis of lung adenocarcinoma in sixty never smokers and identified fourteen new minimal common regions (MCR) of gain or loss, of which five contained a single gene (MOCS2, NSUN3, KHDRBS2, SNTG1 and ST18). One larger MCR of gain contained NSD1. One focal amplification and nine gains contained… CONTINUE READING