Genomic 5-methyldeoxycytidine decreases with age.

  title={Genomic 5-methyldeoxycytidine decreases with age.},
  author={Vincent L. Wilson and Roberts A. Smith and Sheng Ma and Roy G. Cutler},
  journal={The Journal of biological chemistry},
  volume={262 21},
Significant losses of DNA 5-methyldeoxycytidine residues in old age could disrupt cellular gene expression and contribute to the physiological decline of the animal. Thus, the 5-methyldeoxycytidine content of DNAs, isolated from the tissues of two rodent species of various ages, were determined. Mus musculus lost DNA methylation sites at a rate of about 4.7 X 10(4) (approximately 0.012% of the newborn level)/month. Peromyscus leucopus lost DNA 5-methyldeoxycytidine residues at a rate of only 2… CONTINUE READING