Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization.

@article{Hosoya2006GenomewideSO,
  title={Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization.},
  author={Noriko Hosoya and Masashi Sanada and Yasuhito Nannya and Kumi Nakazaki and Li-li Wang and Akira Hangaishi and Mineo Kurokawa and Shigeru Chiba and Seishi Ogawa},
  journal={Genes, chromosomes & cancer},
  year={2006},
  volume={45 5},
  pages={482-94}
}
Chronic myelogenous leukemia (CML) evolves from an indolent chronic phase (CP) characterized by the Philadelphia chromosome. Without effective therapy, it progresses to an accelerated phase (AP) and eventually to a fatal blast crisis (BC). To identify the genes involved in stage progression in CML, we performed a genomewide screening of DNA copy number changes in a total of 55 CML patients in different stages with the use of the high-resolution array-based comparative genomic hybridization… CONTINUE READING

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