Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae.

@article{Vandenbosch2013GenomewideSF,
  title={Genomewide screening for genes involved in biofilm formation and miconazole susceptibility in Saccharomyces cerevisiae.},
  author={Davy Vandenbosch and Evelien De Canck and Inne Dhondt and Petra Rigole and H. J. C. F. Nelis and Tom Coenye},
  journal={FEMS yeast research},
  year={2013},
  volume={13 8},
  pages={720-30}
}
Infections related to fungal biofilms are difficult to treat due to the reduced susceptibility of sessile cells to most antifungal agents. Previous research has shown that 1-10% of sessile Candida cells survive treatment with high doses of miconazole (a fungicidal imidazole). The aim of this study was to identify genes involved in fungal biofilm formation and to unravel the mechanisms of resistance of these biofilms to miconazole. To this end, a screening of a Saccharomyces cerevisiae deletion… CONTINUE READING
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