Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1.

@article{Abecasis2004GenomewideSI,
  title={Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1.},
  author={Gonçalo R. Abecasis and Rachel Burt and Diana Hall and Sylvia Bochum and Kimberly Doheny and S. Laura Lundy and Marie Torrington and J. Louw Roos and Joseph A Gogos and Maria Karayiorgou},
  journal={American journal of human genetics},
  year={2004},
  volume={74 3},
  pages={403-17}
}
We report on our initial genetic linkage studies of schizophrenia in the genetically isolated population of the Afrikaners from South Africa. A 10-cM genomewide scan was performed on 143 small families, 34 of which were informative for linkage. Using both nonparametric and parametric linkage analyses, we obtained evidence for a small number of disease loci… CONTINUE READING