Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexity.

@article{Igo2006GenomewideSF,
  title={Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexity.},
  author={Robert P. Igo and Nicola H. Chapman and Virginia W. Berninger and Mark M Matsushita and Zoran Brkanac and Joseph Rothstein and Ted Holzman and Kathleen Nielsen and Wendy H Raskind and Ellen M. Wijsman},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2006},
  volume={141B 1},
  pages={15-27}
}
Dyslexia is a common learning disability exhibited as a delay in acquiring reading skills despite adequate intelligence and instruction. Reading single real words (real-word reading, RWR) is especially impaired in many dyslexics. We performed a genome scan, using variance components (VC) linkage analysis and Bayesian Markov chain Monte Carlo (MCMC) joint segregation and linkage analysis, for three quantitative measures of RWR in 108 multigenerational families, with follow up of the strongest… CONTINUE READING

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