Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.

  title={Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25.},
  author={L. S. Cheng and Shang-Lun Chiang and H. Tu and Shun-Jen Chang and Tsu-Nai Wang and A. Ko and R. Chakraborty and Y. Ko},
  journal={American journal of human genetics},
  volume={75 3},
Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region. We report here a genomewide linkage study of 21 multiplex pedigrees with gout from an aboriginal tribe in Taiwan. From observations of familial clustering, early onset of gout, and clinically severe manifestations, we hypothesized that a major gene plays a role in… Expand
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