Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method.

@article{Camp2001GenomewideML,
  title={Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method.},
  author={Nicola J. Camp and Susan L. Neuhausen and Josepha Tiobech and A H Polloi and Hilary Coon and Marina Myles-Worsley},
  journal={American journal of human genetics},
  year={2001},
  volume={69 6},
  pages={1278-89}
}
Palauans are an isolated population in Micronesia with lifetime prevalence of schizophrenia (SCZD) of 2%, compared to the world rate of approximately 1%. The possible enrichment for SCZD genes, in conjunction with the potential for reduced etiological heterogeneity and the opportunity to ascertain statistically powerful extended pedigrees, makes Palauans a population of choice for the mapping of SCZD genes. We have used a Markov-chain Monte Carlo method to perform a genomewide multipoint… CONTINUE READING

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