Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.

  title={Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.},
  author={Shenghan Chen and William G Ondo and Shaoqi Rao and Lin Li and Qiuyun Chen and Qing Wang},
  journal={American journal of human genetics},
  volume={74 5},
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%-12% of all whites. To genetically dissect this complex disease, we characterized 15 large and extended multiplex pedigrees, consisting of 453 subjects (134 affected with RLS). A familial aggregation analysis was performed, and SAGE FCOR was used to quantify the total genetic contribution in these families. A weighted average correlation of 0.17 between first-degree relatives was obtained, and heritability was… 

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To the Editor: The authors would like to comment on the Chen et al. (2004) article that addresses the identification of a putative susceptibility locus for restless legs syndrome (RLS) on chromosome 9p, and have several concerns regarding the statistical methodology used.

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Reply to Ray and Weeks: Linkage for Restless Legs Syndrome on Chromosome 9p Is Significant

To the Editor: Ray and Weeks (2005 [in this issue]) discussed some concerns about the statistical methodology of the genomewide linkage-scan study that identified a novel susceptibility locus for restless legs syndrome (RLS) on chromosome 9p24-22, and their arguments may not be the most appropriate.

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