Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.

@article{Chen2004GenomewideLS,
  title={Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.},
  author={Shenghan Chen and William G Ondo and Shaoqi Rao and Lin Li and Qiuyun Chen and Qing Wang},
  journal={American journal of human genetics},
  year={2004},
  volume={74 5},
  pages={
          876-85
        }
}
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%-12% of all whites. To genetically dissect this complex disease, we characterized 15 large and extended multiplex pedigrees, consisting of 453 subjects (134 affected with RLS). A familial aggregation analysis was performed, and SAGE FCOR was used to quantify the total genetic contribution in these families. A weighted average correlation of 0.17 between first-degree relatives was obtained, and heritability was… 

Figures and Tables from this paper

Linkage analysis identifies a novel locus for restless legs syndrome on chromosome 2q in a South Tyrolean population isolate.

The findings reemphasize the genetic heterogeneity of the disorder and strongly support the identification of a novel locus for RLS on chromosome 2q.

No convincing evidence of linkage for restless legs syndrome on chromosome 9p.

To the Editor: The authors would like to comment on the Chen et al. (2004) article that addresses the identification of a putative susceptibility locus for restless legs syndrome (RLS) on chromosome 9p, and have several concerns regarding the statistical methodology used.

A Novel Locus for Restless Legs Syndrome on Chromosome 13q

A genetic linkage at chromosome 13 in a RLS family is demonstrated and this result shows strong genetic linkage to this locus, which supports the genetic heterogeneity in the pathogenesis of this syndrome.

Evidence for linkage of restless legs syndrome to chromosome 9p

A family with a rather homogeneous phenotype and very early disease onset represents a unique opportunity to further elucidate the genetic causes of the frequent restless leg syndrome and demonstrates linkage to a locus on chromosome 9p that is probably distinct from RLS3.

[Advances in genetics of restless legs syndrome].

The most important findings achieved in genetic studies of RLS are reviewed and it is suggested that it is a highly heritable trait with heritability estimates of about 50%.

Fine-Mapping of Restless Legs Locus 4 (RLS4) Identifies a Haplotype over the SPATS2L and KCTD18 Genes

The locus on chromosome 2q33 (RLS4) was identified in two South Tyrolean families who shared a haplotype of microsatellite marker alleles across an 8.2-cM region to pinpoint the gene localisation within RLS4.

Autosomal‐dominant locus for restless legs syndrome in French‐Canadians on chromosome 16p12.1

An autosomal‐dominant locus for Restless Legs Syndrome (RLS) in a French‐Canadian (FC) pedigree is described and copy number variation and karyotype analyses did not reveal any chromosomal abnormality in the region.

Evidence for further genetic locus heterogeneity and confirmation of RLS‐1 in restless legs syndrome

Evidence for linkage on chromosome 12 supports the existence of RLS‐1 and provides evidence for the likelihood of further genetic locus heterogeneity of RLP, and further genome wide linkage analyses have the potential to identify additional RLS loci.

Reply to Ray and Weeks: Linkage for Restless Legs Syndrome on Chromosome 9p Is Significant

To the Editor: Ray and Weeks (2005 [in this issue]) discussed some concerns about the statistical methodology of the genomewide linkage-scan study that identified a novel susceptibility locus for restless legs syndrome (RLS) on chromosome 9p24-22, and their arguments may not be the most appropriate.

Sleep Disorders Medicine

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