Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.

@article{Chen2004GenomewideLS,
  title={Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.},
  author={Shenghan Chen and William G Ondo and Shaoqi Rao and Lin Li and Qiuyun Chen and Qing Wang},
  journal={American journal of human genetics},
  year={2004},
  volume={74 5},
  pages={
          876-85
        }
}
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%-12% of all whites. To genetically dissect this complex disease, we characterized 15 large and extended multiplex pedigrees, consisting of 453 subjects (134 affected with RLS). A familial aggregation analysis was performed, and SAGE FCOR was used to quantify the total genetic contribution in these families. A weighted average correlation of 0.17 between first-degree relatives was obtained, and heritability was… 

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TLDR
To the Editor: The authors would like to comment on the Chen et al. (2004) article that addresses the identification of a putative susceptibility locus for restless legs syndrome (RLS) on chromosome 9p, and have several concerns regarding the statistical methodology used.

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A genetic linkage at chromosome 13 in a RLS family is demonstrated and this result shows strong genetic linkage to this locus, which supports the genetic heterogeneity in the pathogenesis of this syndrome.

Evidence for linkage of restless legs syndrome to chromosome 9p

TLDR
A family with a rather homogeneous phenotype and very early disease onset represents a unique opportunity to further elucidate the genetic causes of the frequent restless leg syndrome and demonstrates linkage to a locus on chromosome 9p that is probably distinct from RLS3.

[Advances in genetics of restless legs syndrome].

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The most important findings achieved in genetic studies of RLS are reviewed and it is suggested that it is a highly heritable trait with heritability estimates of about 50%.

Sleep Disorders Medicine

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