Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.

  title={Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.},
  author={Shenghan Chen and William G Ondo and Shaoqi Rao and Lin Li and Qiuyun Chen and Qing Wang},
  journal={American journal of human genetics},
  volume={74 5},
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%-12% of all whites. To genetically dissect this complex disease, we characterized 15 large and extended multiplex pedigrees, consisting of 453 subjects (134 affected with RLS). A familial aggregation analysis was performed, and SAGE FCOR was used to quantify the total genetic contribution in these families. A weighted average correlation of 0.17 between first-degree relatives was obtained, and heritability was… 

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To the Editor: The authors would like to comment on the Chen et al. (2004) article that addresses the identification of a putative susceptibility locus for restless legs syndrome (RLS) on chromosome 9p, and have several concerns regarding the statistical methodology used.

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[Advances in genetics of restless legs syndrome].

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Studies of penetrance and anticipation in five autosomal‐dominant restless legs syndrome pedigrees

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Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families

The segregation pattern found in the authors' families argues for an autosomal allele acting dominantly in RLS families with an early age at onset of symptoms and suggests that RLS is a causative heterogeneous disease.

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