Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q

@article{Shugart2006GenomewideLS,
  title={Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q},
  author={Yin Yao Shugart and Jack F. Samuels and Virginia L. Willour and Marco A Grados and Benjamin D. Greenberg and James A Knowles and James Thomas Mccracken and Scott L. Rauch and Dennis L. Murphy and Ying W{\'a}ng and Anthony Pinto and Abby J. Fyer and John Piacentini and David L. Pauls and Bernadette A M Cullen and Jesu´s Page and Steven A. Rasmussen and O Joseph Bienvenu and Rudolf Hoehn-Saric and David Valle and Kevin Y. H. Liang and Mark A. Riddle and Gerald Nestadt},
  journal={Molecular Psychiatry},
  year={2006},
  volume={11},
  pages={763-770}
}
Obsessive-compulsive disorder (OCD) is the tenth most disabling medical condition worldwide. Twin and family studies implicate a genetic etiology for this disorder, although specific genes have yet to be identified. Here, we present the first large-scale model-free linkage analysis of both extended and nuclear families using both ‘broad’ (definite and probable diagnoses) and ‘narrow’ (definite only) definitions of OCD. We conducted a genome-scan analysis of 219 families collected as part of the… CONTINUE READING
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