Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations.

@article{Zhang2003GenomewideDO,
  title={Genomewide distribution of high-frequency, completely mismatching SNP haplotype pairs observed to be common across human populations.},
  author={Jinghui Zhang and William L. Rowe and Andrew G. Clark and Kenneth H. Buetow},
  journal={American journal of human genetics},
  year={2003},
  volume={73 5},
  pages={1073-81}
}
Knowledge of human haplotype structure has important implications for strategies of disease-gene mapping and for understanding human evolutionary history. Many attributes of SNPs and haplotypes appear to exhibit highly nonrandom behavior, suggesting past operation of selection or other nonneutral forces. We report the exceptional abundance of a particular haplotype pattern in which two high-frequency haplotypes have different alleles at every SNP site (hence the name "yin yang haplotypes… CONTINUE READING

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