Genomewide association study for susceptibility genes contributing to familial Parkinson disease

  title={Genomewide association study for susceptibility genes contributing to familial Parkinson disease},
  author={Nathan Pankratz and Jemma B. Wilk and Jeanne Latourelle and Anita L. DeStefano and Cheryl A Halter and Elizabeth W. Pugh and Kimberly Doheny and James F. Gusella and William C. Nichols and Tatiana Foroud and Richard H. Myers},
  journal={Human Genetics},
Five genes have been identified that contribute to Mendelian forms of Parkinson disease (PD); however, mutations have been found in fewer than 5% of patients, suggesting that additional genes contribute to disease risk. Unlike previous studies that focused primarily on sporadic PD, we have performed the first genomewide association study (GWAS) in familial PD. Genotyping was performed with the Illumina HumanCNV370Duo array in 857 familial PD cases and 867 controls. A logistic model was employed… CONTINUE READING
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