Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.

@article{Tantisira2011GenomewideAB,
  title={Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.},
  author={Kelan Tantisira and Jessica Lasky-Su and Michishige Harada and Anna Louise Murphy and Augusto A Litonjua and Blanca E. Himes and Christoph Lange and Ross Lazarus and Jody Senter Sylvia and Barbara J. Klanderman and Qing Ling Duan and Weiliang Qiu and Tomomitsu Hirota and Fernando D. Martinez and David T Mauger and Christine A. Sorkness and Stanley J Szefler and Stephen C. Lazarus and Robert F. Lemanske and Stephen P. Peters and J. J. G. Lima and Yusuke Nakamura and Mayumi Tamari and Scott T. Weiss},
  journal={The New England journal of medicine},
  year={2011},
  volume={365 13},
  pages={
          1173-83
        }
}
BACKGROUND The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewide association study would reveal novel pharmacogenetic determinants of the response to inhaled glucocorticoids. METHODS We analyzed a small number of statistically powerful variants selected on the basis of a family-based screening algorithm from among 534,290 single-nucleotide polymorphisms (SNPs) to… CONTINUE READING
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  • 2011

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