Genomewide association analysis of coronary artery disease.

  title={Genomewide association analysis of coronary artery disease.},
  author={Nilesh J. Samani and Jeanette Erdmann and Alistair S. Hall and Christian Hengstenberg and Massimo Mangino and Bjoern Mayer and Richard J. Dixon and Thomas Meitinger and Peter S Braund and Heinz-Erich Wichmann and Jennifer H. Barrett and Inke Regina K{\"o}nig and Suzanne E Stevens and Silke Szymczak and David Alexandre Tregouet and Mark M. Iles and Friedrich Pahlke and Helen Pollard and Wolfgang Lieb and François Cambien and Marcus M. Fischer and Willem Hendrik Ouwehand and Stefan Blankenberg and Anthony J. Balmforth and Andrea Baessler and Stephen G. Ball and Tim Matthias Strom and Ingrid Braenne and Christian Gieger and Panos Deloukas and Martin D. Tobin and Andreas Ziegler and John R. Thompson and Heribert Schunkert},
  journal={The New England journal of medicine},
  volume={357 5},
BACKGROUND Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease. METHODS We first identified chromosomal loci that were strongly associated with coronary artery disease in the Wellcome Trust Case Control Consortium (WTCCC) study (which involved 1926 case subjects with coronary artery disease and 2938 controls) and looked for replication in the German… 

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