Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2

@article{Fischer2017GenomewideAO,
  title={Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2},
  author={Johannes Fischer and Franziska Degenhardt and Andrea Hofmann and Silke Redler and Fitnat Buket Basmanav and Stefanie Heilmann-Heimbach and Sandra Hanneken and Kathrin A. Giehl and Hans Wolff and Susanne Moebus and Roland Kruse and Gerhard Lutz and Bettina Blaumeiser and Markus B{\"o}hm and Natalie Garcia Bartels and Ulrike Blume-Peytavi and Lynn Petukhova and Angela M. Christiano and Markus M. N{\"o}then and Regina C. Betz},
  journal={Experimental Dermatology},
  year={2017},
  volume={26}
}
Alopecia areata (AA) is a common hair loss disorder of autoimmune aetiology, which often results in pronounced psychological distress. Understanding of the pathophysiology of AA is increasing, due in part to recent genetic findings implicating common variants at several genetic loci. To date, no study has investigated the contribution of copy number variants (CNVs) to AA, a prominent class of genomic variants involved in other autoimmune disorders. Here, we report a genomewide‐ and a candidate… 
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Broadening the AA research horizon along the lines suggested above promises not only to open the door to innovative and even more effective immunotherapy strategies for AA but will also likely be relevant for other autoimmune disorders in which pathobiology, ectopic MHC class I expression, and IP collapse play an important role.
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A key goal for effective AA management is the re‐establishment of a functional HF IP, which will also provide superior protection from disease relapse, and may confer increased susceptibility to AA for some individuals.
Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management.
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The essentials of hair bulb IP are reviewed and open questions are discussed and why the systematic dissection of hair bulbs IP and its pharmacological manipulation promise to extend the range of future therapeutic options in AA and other IP collapse-related autoimmune diseases.
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