Genomewide Screening Reveals High Levels of Insertional Polymorphism in the Human Endogenous Retrovirus Family HERV-K(HML2): Implications for Present-Day Activity

@article{Belshaw2005GenomewideSR,
  title={Genomewide Screening Reveals High Levels of Insertional Polymorphism in the Human Endogenous Retrovirus Family HERV-K(HML2): Implications for Present-Day Activity},
  author={R. Belshaw and A. Dawson and John Woolven-Allen and J. Redding and A. Burt and M. Tristem},
  journal={Journal of Virology},
  year={2005},
  volume={79},
  pages={12507 - 12514}
}
ABSTRACT The published human genome sequence contains many thousands of endogenous retroviruses (HERVs) but all are defective, containing nonsense mutations or major deletions. Only the HERV-K(HML2) family has been active since the divergence of humans and chimpanzees; it contains many members that are human specific, as well as several that are insertionally polymorphic (an inserted element present only in some human individuals). Here we perform a genomewide survey of insertional polymorphism… Expand
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