Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice.

@article{Bice2009GenomewideSS,
  title={Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice.},
  author={Paula J. Bice and William Valdar and Lili Zhang and Lixiang Liu and Dongbing Lai and Nicholas J Grahame and Jonathan Flint and T K Li and Lawrence Lumeng and Tatiana Foroud},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 3},
  pages={531-7}
}
BACKGROUND The high and low alcohol preferring (HAP1 and LAP1) mouse lines were selectively bred for differences in alcohol intake. The HAP1 and LAP1 mice are essentially noninbred lines that originated from the outbred colony of HS/Ibg mice, a heterogeneous stock developed from intercrossing 8 inbred strains of mice. METHODS A total of 867 informative SNPs were genotyped in 989 HAP1 x LAP1 F2, 68 F1s, 14 parents (6 LAP1, 8 HAP1), as well as the 8 inbred strains of mice crossed to generate… CONTINUE READING

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