Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.

@article{Oetting2016GenomewideAS,
  title={Genomewide Association Study of Tacrolimus Concentrations in African American Kidney Transplant Recipients Identifies Multiple CYP3A5 Alleles.},
  author={William S Oetting and David P. Schladt and Weihua Guan and MB. Miller and Rory P. Remmel and Casey R. Dorr and Kinjal Sanghavi and Roslyn B Mannon and Blanca Luz Jim{\'e}nez Herrera and AJ. Matas and Dan Salomon and P-Y Kwok and Brendan J. Keating and Ajay K Israni and PA. Jacobson},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2016},
  volume={16 2},
  pages={
          574-82
        }
}
We previously reported that tacrolimus (TAC) trough blood concentrations for African American (AA) kidney allograft recipients were lower than those observed in white patients. Subtherapeutic TAC troughs may be associated with acute rejection (AR) and AR-associated allograft failure. This variation in TAC troughs is due, in part, to differences in the frequency of the cytochrome P450 CYP3A5*3 allele (rs776746, expresses nonfunctional enzyme) between white and AA recipients; however, even after… CONTINUE READING
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