Genomewide Association Study of Severe Covid-19 with Respiratory Failure

  title={Genomewide Association Study of Severe Covid-19 with Respiratory Failure},
  author={D. Ellinghaus and F. Degenhardt and L. Bujanda and M. Buti and Agust{\'i}n Albillos and P. Invernizzi and J. Fern{\'a}ndez and Daniele Prati and Guido Baselli and R. Asselta and M. M. Grimsrud and Chiara Milani and F{\'a}tima Aziz and J. K{\"a}ssens and S. May and Mareike Wendorff and L. Wienbrandt and F. Uellendahl-Werth and Tenghao Zheng and Xiao-li Yi and Ra{\'u}l de Pablo and A. G. Chercoles and Adriana Palom and Alba-Estela Garcia-Fernandez and Francisco Rodriguez-Frias and A. Zanella and A. Bandera and A. Protti and A. Aghemo and Ana Lleo and A. Biondi and Andrea Caballero-Garralda and A. Gori and Anja Tanck and Anna Carreras Nolla and Anna Latiano and A. Fracanzani and A. Peschuck and Antonio Juli{\`a} and A. Pesenti and Antonio Voza and D. Jim{\'e}nez and B. Mateos and Beatriz Nafria Jimenez and C. Quereda and Cinzia Paccapelo and Christoph Gassner and C. Angelini and C. Cea and Aurora Solier and D. Pesta{\~n}a and Eduardo Mu{\~n}iz-Diaz and Elena Sandoval and E. Paraboschi and E. Navas and F{\'e}lix Garc{\'i}a S{\'a}nchez and F. Ceriotti and Filippo Martinelli-Boneschi and F. Peyvandi and F. Blasi and L. T{\'e}llez and A. Blanco-Grau and G. Hemmrich-Stanisak and G. Grasselli and G. Costantino and Giulia Cardamone and G. Foti and Serena Aneli and Hayato Kurihara and H. ElAbd and Ilaria My and Iv{\'a}n Galv{\'a}n-Femenia and J. Mart{\'i}n and J. Erdmann and Jose Ferrusqu{\'i}a-Acosta and Koldo Garcia-Etxebarria and Laura Izquierdo-Sanchez and L. Bettini and Lauro Sumoy and L. Terranova and Leticia Moreira and L. Santoro and Luigia Scudeller and Francisco Mesonero and Luisa Roade and Malte C. R{\"u}hlemann and M. Sch{\"a}fer and Maria Carrabba and Mar Riveiro-Barciela and Maria E Figuera Basso and M. Valsecchi and Mar{\'i}a Hernandez-Tejero and Marialbert Acosta-Herrera and M. D'Angi{\`o} and Marina Baldini and M. Cazzaniga and Martin Schulzky and M. Cecconi and M. Wittig and M. Ciccarelli and Miguel Rodr{\'i}guez-Gand{\'i}a and Monica Bocciolone and Monica Miozzo and N. Montano and Nicole Braun and Nicoletta Sacchi and N. Mart{\'i}nez and Onur {\"O}zer and Orazio Palmieri and Paola Faverio and Paoletta Preatoni and P. Bonfanti and Paolo Omodei and Paolo Tentorio and P. Castro and P. M. Rodrigues and Aaron Blandino Ortiz and R. de Cid and Ricard Ferrer and Roberta Gualtierotti and R. Nieto and Siegfried Goerg and Salvatore Badalamenti and Sara Marsal and G. Matullo and Serena Pelusi and S. Juzenas and Stefano Aliberti and Valter Monzani and V. Moreno and Tanja Wesse and T. Lenz and T. Pumarola and Valeria Rimoldi and S. Bosari and W. Albrecht and W. Peter and M. Romero-G{\'o}mez and M. D'Amato and S. Duga and J. Banales and Johannes R Hov and T. Folseraas and Luca Valenti and Annemarie Franke and Tom H Karlsen},
  journal={The New England Journal of Medicine},
  • D. Ellinghaus, F. Degenhardt, +143 authors Tom H Karlsen
  • Published 2020
  • Medicine
  • The New England Journal of Medicine
  • Abstract Background There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. Methods We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure… CONTINUE READING


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    A Novel Coronavirus from Patients with Pneumonia in China, 2019