Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

@article{Ku2008GenomewideAO,
  title={Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains},
  author={Manching Ku and R. Koche and Esther Rheinbay and Eric M. Mendenhall and M. Endoh and T. Mikkelsen and A. Presser and C. Nusbaum and Xiaohui Xie and A. Chi and Mazhar Adli and S. Kasif and L. Ptaszek and C. Cowan and E. Lander and H. Koseki and B. Bernstein},
  journal={PLoS Genetics},
  year={2008},
  volume={4}
}
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2,000 genes. To gain insight into the structure and function of bivalent domains, we mapped key histone modifications and subunits of Polycomb-repressive complexes 1 and 2 (PRC1 and PRC2) genomewide in human and mouse ES cells by chromatin immunoprecipitation, followed by ultra high… Expand
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA
Polycomb-like proteins link the PRC2 complex to CpG islands
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The interaction of PRC2 with RNA or chromatin is mutually antagonistic.
Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation
Recruiting polycomb to chromatin.
Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms
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