Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements.

@article{Cecco2013GenomesOR,
  title={Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements.},
  author={Marco De Cecco and Steven W. Criscione and Edward Joseph Peckham and Sara Hillenmeyer and Eliza A Hamm and Jayameenakshi Manivannan and Abigail L. Peterson and Jill A Kreiling and Nicola Neretti and John M. Sedivy},
  journal={Aging cell},
  year={2013},
  volume={12 2},
  pages={
          247-56
        }
}
Replicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regulatory elements (FAIRE) to map genome-wide chromatin conformations. In contrast to growing cells, whose genomes are rich with features of both open and closed chromatin, FAIRE… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 99 CITATIONS, ESTIMATED 60% COVERAGE

Death by transposition – the enemy within?

  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2013
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

The hallmarks of fibroblast ageing

  • Mechanisms of Ageing and Development
  • 2014
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 18 Citations per year over the last 3 years

  • 8% Increase in citations per year in 2018 over 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Epigenetic changes in senescent

M. De Cecco
  • 2013

Similar Papers

Loading similar papers…