Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome

@article{Mu2007GenomewideVA,
  title={Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome},
  author={Jianbing Mu and Philip Awadalla and Junhui Duan and Kate M. McGee and Jon Keebler and Karl Seydel and Gilean McVean and Xin-zhuan Su},
  journal={Nature Genetics},
  year={2007},
  volume={39},
  pages={126-130}
}
One goal in sequencing the Plasmodium falciparum genome, the agent of the most lethal form of malaria, is to discover vaccine and drug targets. However, identifying those targets in a genome in which ∼60% of genes have unknown functions is an enormous challenge. Because the majority of known malaria antigens and drug-resistant genes are highly polymorphic and under various selective pressures, genome-wide analysis for signatures of selection may lead to discovery of new vaccine and drug… CONTINUE READING

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