Genome-wide transcriptional responses of Escherichia coli to glyphosate, a potent inhibitor of the shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase.

@article{Lu2013GenomewideTR,
  title={Genome-wide transcriptional responses of Escherichia coli to glyphosate, a potent inhibitor of the shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase.},
  author={W. Lu and L. Li and M. Chen and Zhengfu Zhou and W. Zhang and S. Ping and Y. Yan and J. Wang and Min Lin},
  journal={Molecular bioSystems},
  year={2013},
  volume={9 3},
  pages={
          522-30
        }
}
  • W. Lu, L. Li, +6 authors Min Lin
  • Published 2013
  • Biology, Medicine
  • Molecular bioSystems
  • The shikimate pathway enzymes offer attractive targets for the development of antimetabolites. Glyphosate is an effective antimetabolite that inhibits 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase in the shikimate pathway, thereby resulting in a shortage of the chorismate-derived essential aromatic amino acids. However, little is known about the genome-wide transcriptional responses of bacteria to glyphosate shock. In the current study, a transcriptome analysis of Escherichia coli (E. coli… CONTINUE READING
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