Genome-wide transcriptional responses of Escherichia coli to glyphosate, a potent inhibitor of the shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase.

@article{Lu2013GenomewideTR,
  title={Genome-wide transcriptional responses of Escherichia coli to glyphosate, a potent inhibitor of the shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase.},
  author={Wei Lu and Liang Li and Ming Chen and Zhengfu Zhou and Wei Zhang and Shuzhen Ping and Yongliang Yan and Jin Wang and Min Lin},
  journal={Molecular bioSystems},
  year={2013},
  volume={9 3},
  pages={
          522-30
        }
}
The shikimate pathway enzymes offer attractive targets for the development of antimetabolites. Glyphosate is an effective antimetabolite that inhibits 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase in the shikimate pathway, thereby resulting in a shortage of the chorismate-derived essential aromatic amino acids. However, little is known about the genome-wide transcriptional responses of bacteria to glyphosate shock. In the current study, a transcriptome analysis of Escherichia coli (E. coli… CONTINUE READING

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