Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures.

@article{Kathpalia2006GenomewideTP,
  title={Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures.},
  author={Vinnie P Kathpalia and Erich N Mussak and Selwyn S Chow and Phillip H Lam and Nathan Wm Skelley and Michael Time and Robert J Markelewicz and Darja Kanduc and Lucy Lomas and Zhaoying Xiang and Animesh A. Sinha},
  journal={The Journal of dermatology},
  year={2006},
  volume={33 5},
  pages={309-18}
}
The elucidation of specific genetic changes associated with human cancer pathogenesis has focused efforts to relate such changes to the neoplastic phenotype. To further our understanding of the genetic basis of human squamous cell carcinoma (SCC) of the skin, this study used a genome-wide (12 627 sequences) approach to determine transcriptional signatures in lesional and nonlesional sites from five SCC patients. Several novel genes involving the p53 pathway, anti-apoptotic pathways, signal… CONTINUE READING
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