Genome-wide transcriptional analyses of Chinese patients reveal cell migration is attenuated in IDH1-mutant glioblastomas.

@article{Hu2015GenomewideTA,
  title={Genome-wide transcriptional analyses of Chinese patients reveal cell migration is attenuated in IDH1-mutant glioblastomas.},
  author={Huimin Hu and Zheng Wang and Yanwei Liu and Chuanbao Zhang and Mingyang Li and Wenlong Zhang and Kuanyu Wang and Jinquan Cai and Wen Cheng and Hua Huang and Tao Jiang},
  journal={Cancer letters},
  year={2015},
  volume={357 2},
  pages={
          566-74
        }
}
Patients with isocitrate dehydrogenase 1 (IDH1)-mutant glioblastoma exhibit increased survival compared with those with wild-type IDH1 tumors. The magnitude of this finding has led to the use of IDH1 mutations as diagnostic and prognostic biomarkers. However, the mechanisms underlying the reported correlation between the IDH1 mutation and increased survival have not been fully revealed. In this work, based on genome-wide transcriptional analyses of 69 Chinese patients with glioblastoma, we have… CONTINUE READING
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