Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis.

  title={Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis.},
  author={Yukio Kurihara and Akihiro Matsui and Kousuke Hanada and Makiko Kawashima and Junko Ishida and Taeko Morosawa and Maho Tanaka and Eli Kaminuma and Yoshiki Mochizuki and Akihiro Matsushima and Tetsuro Toyoda and Kazuo Shinozaki and Motoaki Seki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 7},
The nonsense-mediated mRNA decay (NMD) pathway is a well-known eukaryotic surveillance mechanism that eliminates aberrant mRNAs that contain a premature termination codon (PTC). The UP-Frameshift (UPF) proteins, UPF1, UPF2, and UPF3, are essential for normal NMD function. Several NMD substrates have been identified, but detailed information on NMD substrates is lacking. Here, we noticed that, in Arabidopsis, most of the mRNA-like nonprotein-coding RNAs (ncRNAs) have the features of an NMD… CONTINUE READING
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