Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

  title={Genome-wide study for circulating metabolites identifies 62 loci and reveals novel
systemic effects of LPA},
  author={Johannes Kettunen and Ayşe Demirkan and Peter W{\"u}rtz and Harmen H. M. Draisma and Toomas Haller and Rajesh Rawal and Anika A. M. Vaarhorst and Antti J. Kangas and Leo-Pekka Lyytik{\"a}inen and Matti Pirinen and Ren{\'e} Pool and Antti-Pekka Sarin and Pasi Soininen and Taru Tukiainen and Qin Wang and Mika Tiainen and Tuulia Tynkkynen and Najaf Amin and Tanja Zeller and Marian Beekman and Joris Deelen and Ko Willems van Dijk and T{\"o}nu Esko and Jouke-Jan Hottenga and Elisabeth M. van Leeuwen and Terho Lehtim{\"a}ki and Evelin Mihailov and Richard J. Rose and Anton J. M de Craen and Christian Gieger and Mika A. P. K{\"a}h{\"o}nen and Markus Perola and Stefan S Blankenberg and Markku J. Savolainen and Aswin Verhoeven and Jorma S. A. Viikari and Gonneke A H M Willemsen and Dorret I. Boomsma and Cornelia M van Duijn and Johan G Eriksson and Antti Jula and Marjo-Riitta J{\"a}rvelin and Jaakko Kaprio and Andres Metspalu and Olli T. Raitakari and Veikko V Salomaa and Pieternella E Slagboom and Melanie Waldenberger and Samuli Ripatti and Mika Ala-Korpela},
  booktitle={Nature communications},
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide association study of genetic influences on 123 circulating metabolic traits quantified by nuclear magnetic resonance… CONTINUE READING
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