Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.

@article{Hazra2009GenomewideSP,
  title={Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.},
  author={A. Dey Hazra and Peter Kraft and Ross Lazarus and Constance M. Chen and Stephen J. Chanock and Paul H Jacques and Jacob S Selhub and David J. Hunter},
  journal={Human molecular genetics},
  year={2009},
  volume={18 23},
  pages={4677-87}
}
Low plasma B-vitamin levels and elevated homocysteine have been associated with cancer, cardiovascular disease and neurodegenerative disorders. Common variants in FUT2 on chromosome 19q13 were associated with plasma vitamin B12 levels among women in a genome-wide association study in the Nurses' Health Study (NHS) NCI-Cancer Genetic Markers of Susceptibility (CGEMS) project. To identify additional loci associated with plasma vitamin B12, homocysteine, folate and vitamin B6 (active form… CONTINUE READING
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