Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.

@article{Frank2012GenomewideSA,
  title={Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.},
  author={Josef Frank and Sven Cichon and Jens Treutlein and Monika Ridinger and Manuel Mattheisen and Per Hoffmann and Stefan Herms and Norbert Wodarz and Michael Soyka and Peter Zill and Wolfgang Maier and Rainald Moessner and Wolfgang Gaebel and Norbert Dahmen and N. Scherbaum and Christine Schm{\"a}l and Michael Steffens and Susanne Lucae and Marcus Ising and Bertram M{\"u}ller-Myhsok and Markus M. N{\"o}then and Karl Mann and Falk Kiefer and Marcella Rietschel},
  journal={Addiction biology},
  year={2012},
  volume={17 1},
  pages={171-80}
}
Alcohol dependence (AD) is an important contributory factor to the global burden of disease. The etiology of AD involves both environmental and genetic factors, and the disorder has a heritability of around 50%. The aim of the present study was to identify susceptibility genes for AD by performing a genome-wide association study (GWAS). The sample comprised 1333 male in-patients with severe AD according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and 2168 controls… CONTINUE READING
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