Genome-wide signatures of male-mediated migration shaping the Indian gene pool

@article{ArunKumar2015GenomewideSO,
  title={Genome-wide signatures of male-mediated migration shaping the Indian gene pool},
  author={GaneshPrasad ArunKumar and Tatiana V. Tatarinova and Jeff Duty and Debra Rollo and Adhikarla Syama and Varatharajan Santhakumari Arun and Valampuri John Kavitha and Petr Tř{\'i}ska and Bennett Greenspan and R. Spencer Wells and Ramasamy Pitchappan and Christina J Elena Oleg Jaume Andrew C David Alan Clio SI Mat Adlera Balanovska Balanovsky Bertranpetit Clarke C and Christina J Adlera and Elena Vladimirovna Balanovska and Oleg P. Balanovsky and Jaume Bertranpetit and Andrew C. Clarke and David Comas and Alan Cooper and Clio Der Sarkissian and Matthew C. Dulik and Jill B Gaieski and Wolfgang Haak and Marc Haber and Angela Hobbs and Asif Javed and Li Jin and Matthew E. Kaplan and Shilin Li and Bego{\~n}a Mart{\'i}nez-Cruz and Elizabeth A. Matisoo-Smith and Marta Mel{\'e} and Nirav C. Merchant and Robert John Mitchell and Amanda Owings and Laxmi Parida and Daniel E. Platt and Llu{\'i}s Quintana-Murci and Colin Renfrew and Daniela R. Lacerda and Ajay K. Royyuru and Theodore G. Schurr and Fabr{\'i}cio Rodrigues Santos and Himla Soodyall and David F. Soria Hernanz and Pandikumar Swamikrishnan and Chris Tyler-Smith and Pedro Paulo R. Vieira and Miguel G. Vilar and R. Spencer Wells and Pierre A. Zalloua and Janet S. Ziegle},
  journal={Journal of Human Genetics},
  year={2015},
  volume={60},
  pages={493-499}
}
Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various… 

Application of geographic population structure (GPS) algorithm for biogeographical analyses of populations with complex ancestries: a case study of South Asians from 1000 genomes project

The findings reflect that the GPS approach is useful but likely overtly dependent on the relative proportions of admixture in the reference populations for determination of the biogeographical origins of test individuals.

Genetic characterisation of the North-West Indian populations: analysis of mitochondrial DNA control region variations

This preliminary study investigated the mitochondrial DNA control region variations in diverse ethnic groups of North-West India for which population data is insufficient and ascertained high gene diversity in the studied maternal lineages.

Genetic perspective of uniparental mitochondrial DNA landscape on the Punjabi population, Pakistan

The vast array of mtDNA variants displayed in this study suggested that the haplogroup composition radiates signals of extensive genetic conglomeration, population admixture and demographic expansion that was equipped with diverse origin, whereas matrilineal gene pool was phylogeographically homogenous across the Punjab.

Ancient Human Migrations to and through Jammu Kashmir- India were not of Males Exclusively

High maternal diversity and phylogenetic analyses suggest that the migrations post-Pleistocene were not strictly paternal, as described in the literature, and highlight the need for an extensive study of the endogamous populations of the region to unravel many facts and find links in the peopling of India.

Historic migration to South Asia in the last two millennia: A case of Jewish and Parsi populations

In this study, a broad genetic profile of Indian Jews and Parsis is reconstructed to paint a fine-grained picture of these ethnic groups.

Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe

This project has patched the hole in the genetic map of Eurasia by demonstrating complexity of genetic structure of Northern Eurasians, existence of East-West and North-South genetic gradients, and assessed different inputs of ancient populations into modern populations.

Contrasting maternal and paternal genetic histories among five ethnic groups from Khyber Pakhtunkhwa, Pakistan

Pakistani populations Gujars, Syeds and Yousafzais showed strong paternal genetic affinities with other Pakistani and Central Asian populations, whereas Jadoons and Tanolis had close affinITIES with Turkmen populations from Central Asia and ethnic groups from northeast India.

Mitochondrial DNA diversity in the Khattak and Kheshgi of the Peshawar Valley, Pakistan

These mtDNA data allow us to begin reconstructing the origins of the Khattak and Kheshgi and describe their complex interactions with populations from the surrounding regions.

Folklore Versus Genetics: A Mitochondrial DNA Investigation About the Origin and Antiquity of the Adi Sub-tribes of Arunachal Pradesh, India

The results based on mtDNA is in agreement with Adi folklore accounts of their historical warfare conflicts and tribal feuds which resulted in their fission–fusion population structure among the Adi regional populations.

References

SHOWING 1-10 OF 47 REFERENCES

A prehistory of Indian Y chromosomes: evaluating demic diffusion scenarios.

The Y-chromosomal data consistently suggest a largely South Asian origin for Indian caste communities and therefore argue against any major influx, from regions north and west of India, of people associated either with the development of agriculture or the spread of the Indo-Aryan language family.

Population Differentiation of Southern Indian Male Lineages Correlates with Agricultural Expansions Predating the Caste System

The utility of detailed local genetic studies within India, without prior assumptions about the importance of Varna rank status for population grouping, is highlighted to obtain new insights into the relative influences of past demographic events for the population structure of the whole of modern India.

Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists.

The reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape.

Genetic Imprints of Pleistocene Origin of Indian Populations: A Comprehensive Phylogeographic Sketch of Indian Y-Chromosomes

It is proposed that the present day Dravidian speaking populations of South India are the descendants of earliest Pleistocene settlers while Austro-Asiatic speakers came from SE Asia in a later migration event.

Ethnic India: a genomic view, with special reference to peopling and structure.

We report a comprehensive statistical analysis of data on 58 DNA markers (mitochondrial [mt], Y-chromosomal, and autosomal) and sequence data of the mtHVS1 from a large number of ethnically diverse

Population genetic structure in Indian Austroasiatic speakers: the role of landscape barriers and sex-specific admixture.

It is proposed that AA speakers in India today are derived from dispersal from southeast Asia, followed by extensive sex-specific admixture with local Indian populations, strongly supporting the first of the two hypotheses.

Separating the post-Glacial coancestry of European and Asian Y chromosomes within haplogroup R1a

The diversity and frequency profiles of M458 suggest its origin during the early Holocene and a subsequent expansion likely related to a number of prehistoric cultural developments in the region, and the virtual absence of M 458 chromosomes outside Europe speaks against substantial patrilineal gene flow from East Europe to Asia, including to India, at least since the mid-Holocene.

Mitochondrial DNA analysis reveals diverse histories of tribal populations from India

Analysis of the first hypervariable region of the mitochondrial DNA (mtDNA) control region in 752 individuals from 17 tribal and four nontribal groups from the Indian subcontinent suggested that caste and tribal groups are genetically similar with respect to mtDNA variation.

Phylogeography of mtDNA haplogroup R7 in the Indian peninsula

Among Indo-Europeans, and particularly in Dravidians, the haplogroup is, despite its lower frequency, phylogenetically more divergent, while among the Munda speakers only one sub-clade of R7, i.e. R7a1, can be observed.

Population and genomic lessons from genetic analysis of two Indian populations

This analysis of high-density genotyping and whole-exome sequencing data of a North and a South Indian population highlights the importance of considering demography for design and analysis of genetic studies, as well as the need for extending human genetic variation catalogs to new populations and particularly to those with particular demographic histories.