Genome-wide screening for target regions of histone deacetylases in cardiomyocytes.

@article{Kaneda2005GenomewideSF,
  title={Genome-wide screening for target regions of histone deacetylases in cardiomyocytes.},
  author={Ruri Kaneda and Shuichi Ueno and Yoshihiro Yamashita and Young Lim Choi and Koji Koinuma and Shuji Takada and Tomoaki Wada and Kazuyuki Shimada and Hiroyuki Mano},
  journal={Circulation research},
  year={2005},
  volume={97 3},
  pages={
          210-8
        }
}
The acetylation status of core histones in cardiomyocytes has been linked to the development of cardiac hypertrophy and heart failure. Little is known, however, of the genes affected by abnormal histone acetylation in such pathological conditions. We recently developed a genome-wide screening method, differential chromatin scanning (DCS), to isolate genomic fragments associated with histones subject to differential acetylation. We have now applied DCS to H9C2 rat embryonic cardiomyocytes… CONTINUE READING

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