Genome-wide screening for gene function using RNAi in mammalian cells.

@article{Cullen2005GenomewideSF,
  title={Genome-wide screening for gene function using RNAi in mammalian cells.},
  author={Lara M. Cullen and Greg M. Arndt},
  journal={Immunology and cell biology},
  year={2005},
  volume={83 3},
  pages={
          217-23
        }
}
Mammalian genome sequencing has identified numerous genes requiring functional annotation. The discovery that dsRNA can direct gene-specific silencing in both model organisms and mammalian cells through RNA interference (RNAi) has provided a platform for dissecting the function of independent genes. The generation of large-scale RNAi libraries targeting all predicted genes within mouse, rat and human cells, combined with the large number of cell-based assays, provides a unique opportunity to… CONTINUE READING

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